BCL-2
BCL-2 encodes an integral outer mitochondrial membrane protein that blocks apoptotic death in certain cells, such as lymphocytes. Constitutive expression of BCL-2, such as occurs when BCL-2 is translocated to the immunoglobulin (Ig) heavy chain locus, is thought to be a primary driver of follicular lymphoma. BCL-2 exerts its survival function in response to a wide range of apoptotic stimuli by inhibiting the release of mitochondrial cytochrome c. Additionally, it has been implicated in modulating mitochondrial calcium homeostasis and proton flux.
- Description
- Additional information
Description
| Product Categories | Primary Antibody |
| Brand | Guangzhou ARUNA Science and Technology |
| Product Name | [Guangzhou ARUNA Science and Technology] Bcl-2 |
| Item number | GAST-01556 |
| Application | WB;IHC;IF |
| Specificity | Human; rat; mouse; rabbit; dog |
| Specification | 50μl, 100μl, 20μl |
| Alias | PPP1R50 (Bcl 2, Bcl2) |
| Clone type | Polyclonal antibodies |
| Predicted molecular weight | Predicted band size: 26 kDa Observed band size: 26 kDa |
| Concentration | >1 mg/ml |
| Recommended dilution ratio | WB 1:500-1:1000 IHC 1:100-1:200 IF 1:200 |
| Immunogen | Synthesis of Bcl-2 polypeptide |
| Antibody source | Rabbit |
| Element | Affinity-purified antibody: 20 mM PBS, 150 mM NaCl, 100 μg/ml BSA, 50% glycerol, sodium azide <0.02%. |
Additional information
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| Size | 50μl, 100μl |